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Luigi Perotti

Assistant Professor

Department: Mechanical and Aerospace Engineering
Phone: 407-823-4445
Office: Engineering I Room 315
Website: Computational Biomechanics Lab
Resume: N/A

Luigi Perotti received his laurea (B.S./M.S.) degree in civil engineering from Politecnico di Milano, Italy, in 2004. Subsequently, he continued his studies in mechanical engineering at the California Institute of Technology where he received his M.S. in 2006 and his Ph.D. with a minor in applied and computational mathematics in 2011. At the end of 2011, he joined Professor Klug’s group in the mechanical and aerospace engineering department at UCLA to pursue his research interests in biomechanics. Since then he has worked on several multidisciplinary projects involving collaborations across the departments of physics, radiology, and the school of medicine.

In 2014, he received the American Heart Association postdoctoral fellowship and joined Professor Ennis' group in the bioengineering and radiological sciences departments at UCLA to develop advanced methods for evaluating cardiac mechanics of the failing heart. In 2017, he received an NIH K25 Mentored Quantitative Research Career Development Award to continue his research on combining computational models with MRI data and conduct pre-clinical studies. Perotti joined the mechanical and aerospace engineering department at UCF in 2019.

Research Interests: Biomechanics, Cardiac mechanics, Electrophisiology, Virus assembly and maturation, Bioinspired deployable shells

  • Assistant Professor
  • Dharmavaram, S., & Perotti, L. E. (2020). A Lagrangian formulation for interacting particles on a deformable medium. Computer Methods in Applied Mechanics and Engineering, 364, 112949.

  • Li, X., Perotti, L. E., Martinez, J. A., Duarte-Vogel, S., Ennis, D. B., & Wu, H. H. (2020). Real-time 3T MRI-guided cardiovascular catheterization in a porcine model using a glass-fiber epoxy-based guidewire. PLOS One, 15 (2), e0229711.

  • Verzhbinsky, I. A., Perotti, L. E., Moulin, K., Cork, T. E., Loecher, M. & Ennis, D. B. (2020). Estimating aggregate cardiomyocyte strain using in vivo diffusion and displacement encoded MRI. IEEE Transactions on Medical Imaging, 39(3), 656-667.

  • Ponnaluri, V. S., Verzhbinsky, I. A., Eldredge, J., Garfinkel, A., Ennis, D. B., & Perotti, L. E. (2019, June). Model of left ventricular contraction: Validation criteria and boundary conditions. International Conference on Imaging and Modeling of the Heart. Bordeaux, France.

  • T. E., Cork, Perotti, L. E., Verzhbinsky, I. A., Loecher, M., & Ennis, D. B. (2019, June). High-resolution ex vivo microstructural MRI after restoring ventricular geometry via 3D printing. Functional Imaging and Modeling of the Heart. Bordeaux, France.

  • Perotti, L. E., Zhang, K., Bruinsma, R. F. & Rudnick, J. (2019). Kirigami and the Caspar-Klug construction for viral shells with negative Gauss curvature. Physical Review E, 99(2), 022413.

  • Verzhbinsky, I. A., Magrath, P., Aliotta, E., Ennis, D. B., & Perotti, L. E. (2018). Time resolved displacement-based registration of in vivo cDTI cardiomyocyte orientations. Proceedings of the IEEE 15th International Symposium on Biomedical Engineering, 474-478.

  • Perotti, L. E., Ponnaluri, A. V., Krishnamoorthi, S., Balzani, D., Ennis, D. B. & Klug, W. S. (2017). Method for the unique identification of hyperelastic material properties using full‐field measures: Application to the passive myocardium material response. International Journal for Numerical Methods in Biomedical Engineering, 33(11), e2866.

  • Perotti, L. E., Magrath, P., Verzhbinsky, I. A., Aliotta, E., Moulin, K. & Ennis, D. B. (2017). Microstructurally anchored cardiac kinematics by combining in vivo DENSE MRI and cDTI. Functional Imaging and Modeling of the Heart, 381-391.

  • Ponnaluri, V., Perotti, L. E., Ennis, D. B., & Klug, W. S. (2017). A viscoactive constitutive modeling framework with variational updates for the myocardium. Computer Methods in Applied Mechanics and Engineering, 314, 85-101.

  • Perotti, L. E., Dharmavaram, S., Klug, W. S., Marian, J., Rudnick, J. & Bruinsma, R. F. (2016). Useful scars: Physics of the capsids of archaeal viruses. Physical Review E, 94(1), 012404.

  • Ponnaluri, A. V., Perotti, L. E., Liu, M., Qu, Z., Weiss, J. N., Ennis, D. B., Klug, W. S. & Garfinkel, A. (2016). Electrophysiology of heart failure using a rabbit model: From the failing myocyte to ventricular fibrillation. PLOS Computational Biology, 12(6), e1004968.