Designs materials for medical devices using human body molecules

Elizabeth Brisbois,

Assistant Professor

Dept of Materials Science and Engineering

407-823-0734

elizabeth.brisbois@ucf.edu

Office: Engineering 1, Room 448

http://mse.ucf.edu/brisboislab/

She is Also:

PI, UCF Therapeutic Biomaterial Interfaces Lab

Prosthetic Interfaces Cluster

“I hope our research helps to eliminate the 1.7 million hospital-acquired infections each year by replacing medical devices made with foreign substances with molecules that exist in our bodies.”

Research

Today, many medical devices such as catheters, grafts, and life support circuits still have significant compatibility challenges, which can lead to severe and undesirable complications such as thrombosis and infection. Brisbois is intent on finding a better way. Her research focuses on the design and development of materials for medical devices using molecules that exist in our bodies to enhance compatibility and reduce complication.

Societal Impact

The CDC reports that in the U.S. there are 1.7 million hospital-acquired infections that cause up to 99,000 deaths and result in $28-$45 billion in associated costs. Brisbois is making it her life’s work to change those statistics. Her vision is to develop new materials that will have a dramatic impact on healthcare throughout the globe. Every day, Brisbois and her team works to mimic the nitric oxide that our body produces to develop materials that are resistant to clotting and infection. These biocompatible nitric oxide materials will eliminate the need for anticoagulants with blood-contacting devices, such as catheters, vascular grafts and extracorporeal life support, removing the risks of infection.

Graduate Students and Achievements

Currently advising two master’s students

Graduate student achievement: ORC Doctoral Fellowship

Education

NIH Postdoctoral Fellow, University of Michigan Medical School

Ph.D. Chemistry, University of Michigan, 2014

M.S. Chemistry, University of Michigan, 2010

B.S. Chemistry, Concordia University Nebraska, 2008

B.S. Ed. Secondary Education, Concordia University Nebraska, 2008

 

 

Current Project

Brisbois and her team designs materials and devices that can deliver nitric oxide, a therapeutic agent which acts as a biological antiplatelet, antimicrobial, vasodilator, and wound healing agent.

Using electrochemistry, nanomaterials, and controlled-delivery principles, they develop polymeric and composite biomaterials that can deliver nitric oxide, then study the interaction between biomedical materials and the physiological environment to engineer antibacterial and thromboresistant medical device coatings.

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Courses She Teaches

EMA 5588: Biocompatibility of Materials

EMA 5104: Structure and Properties of Materials

EMA 5060: Polymer Science and Engineering

Laboratory

The Therapeutic Biomaterial Interfaces Lab conducts interdisciplinary studies focused on the interface of materials, chemistry, bioengineering, biology, and medicine. Its goal is to advance its research from benchtop to bedside using Nitric Oxide (NO) analyzers, antimicrobial testing, and blood compatibility testing.

 

Discoveries/Publication Highlights

Brisbois has 22 journal articles published.

Awards/Grants

NSF-REU Scholar, University of Kansas

NSF-REU Scholar, Colorado State University

Society for Biomaterials STAR Award

University of Michigan Chemistry Research Excellence Fellowship

NIH F32 NRSA Individual Postdoctoral Fellowship

MICHR PTSP Career Development Award

Baxter Young Investigator Award